Publications

	Develop Tandem Tension Sensor to Gauge Integrin-transmitted Molecular Forces G. Niraula*, A. Pyne* and X. Wang  * Equal contribution ACS Sensors 2024 Accepted
	Develop a ratiometric tension sensor exclusively responding to integrin tension magnitude in live cells A.Sarkar*, G. Niraula*, D. N. LeVine, Y. Zhao, Y. Tu, K. Mollaeian, J. Ren, L. Que and X. Wang  * Equal contribution ACS Sensors 2023 Link
	Vinculin transmits high-level integrin tensions that are dispensable for focal adhesion formation J. Austin, Y. Tu, K. Pal and X. Wang Biophysical Journal 2023 Link
	Imaging Cell Adhesive Force at the Single Molecule Level Y. Tu and X. Wang Methods Molecular Biology, Vol. 2600 2022 Book chapter
	Filopodial adhesive force in discrete nodes revealed by integrin molecular tension imaging Y. Tu, K. Pal, J. Austin and X. Wang Current Biology 2022 Link
	Single-Molecule Force Imaging Reveals That Podosome Formation Requires No Extracellular Integrin-Ligand Tensions or Interactions K. Pal, Y. Tu and X. Wang ACS Nano 2022 Link
	Tracking cell migration by cellular force footprint recorded with a mechano-optical biosensor Y. Tu and X. Wang Biosensors and Bioelectronics 2021 Link
	Microfluidic chip grafted with integrin tension sensors for evaluating the effects of flowing shear stress and ROCK inhibitor on platelets S. Mao*, A. Sarkar*, Y. Wang, C. Song, D. N. LeVine, X. Wang** and L. Que**,  ** Equal contribution Lab on a chip   2021 Link
	Ubiquitous Membrane-bound DNase Activity in Podosomes and Invadopodia K. Pal, Y. Zhao, Y. Wang and X. Wang Journal of Cell Biology 2021 Link
	Recent Advances in Cell Adhesive Force Microscopy Y. Tu and X. Wang Sensors 2020 Link
	Cell migration driven by self-generated integrin ligand gradient on ligand-labile surfaces A. Sarkar, D. N. LeVine, N. Kuzmina, Y. Zhao and X, Wang Current Biology 2020 Link
	Cellular force nanoscopy with 50 nm resolution based on integrin molecular tension imaging and localization Y. Zhao, K. Pal, Y. Tu and X. Wang Journal of the American Chemical Society 2020 Link
	Peptide nucleic acid based tension sensor for cellular force imaging with strong DNase resistance Y. Zhao, A. Sarkar and X. Wang Biosensors and Bioelectronics 2020 Link
	Imaging integrin tension and cellular force at submicron resolution with integrative tension sensor Y. Zhao, N. Wetter and X. Wang Journal of Visualized Experiments 2019 Link
	Optical sensor revealed abnormal nuclease spatial activity on cancer cell membrane Y. Wang, Y. Zhao, A. Sarkar, X. Wang Journal of Biophotonics 2019 Link
	Keratocytes Generate High Integrin Tension at the Trailing Edge to Mediate Rear De-adhesion during Rapid Cell Migration Y. Zhao, Y. Wang, A. Sarkar and X. Wang iScience 2018 Link
	Force-activatable coating enables high-resolution cellular force imaging directly on regular cell culture surfaces A. Sarkar, Y. Zhao, Y. Wang and X. Wang Physical Biology 2018 Link
	Towards single-cell single-molecule pull-down X. Wang, S. Park, L. Zeng, A. Jain and T. Ha Biophysical Journal 2018 Link
	Force-activatable biosensor enabling single platelet force mapping directly by fluorescence imaging Y. Wang, D. N. LeVine, M. Gannon, Y. Zhao, A. Sarkar, B. Hoch and X. Wang Biosensors and Bioelectronics 2018 Link
	Integrins outside focal adhesions transmit tensions during stable cell adhesion Y. Wang and X. Wang Scientific Reports 2016 Link

 

Prior to ISU

Z. Rahil, S. Pedron, X. Wang, T. Ha, B. Harley and D. Leckband, Nanoscale mechanics guides cellular decision making. Integrative Biology, 8 (9):929-35 (2016)

M. K. Lee, J. Park, X. Wang, M. Roein-Peikar, E. Ko, E. Qin, J. Lee, T. Ha and H. Kong, “Rupture force of cell adhesion ligand tethers modulates biological activities of a cell-laden hydrogel”, Chemical Communications, 52, 4757, (2016)

F. Chowdhury, I. T. S. Li, T. T. M. Ngo, B. J. Leslie, B. C. Kim, J. E. Sokoloski, E. Weiland, X. Wang, Y. R. Chemla, T. M. Lohman, T. Ha, "Defining Single Molecular Forces Required for Notch Activation Using Nano Yoyo"  Nano Letters, 16(6), 3892-2897 (2016)

X. Wang, Z. Rahil, I. T. S. Li, F. Chowdury, D. Leckband, Y. Chemla and T. Ha, “Constructing modular and universal single molecule tension sensor using protein G to study mechano-sensitive receptors”, Scientific Reports, 6, 21584 (2016)

M. Roein-Peikar, Q. Xu, X. Wang, and T. Ha, “Ultrasensitivity of cell adhesion to the presence of mechanically strong ligands”, Physical Review X, 6, 011001, (2016)

X. Wang*, J. Sun, Q. Xu, F. Chowdury, M. Rokhai, Y. Wang and T. Ha, “Integrin Molecular Tension within Motile Focal Adhesions”, Biophysical Journal, 109, 2259-2267 (2015) (* corresponding author)

F. Chowdhury, I. T. S. Li, B. J. Leslie, S. Doganay, R. Singh, X. Wang, J. Seong, S. H. Lee, S. Park, N. Wang and T. Ha , "Single molecular force across single integrins dictates cell spreading ", Integrative Biology, 7, 1265-1271 (2015)

X. Wang and T. Ha, "Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling", Science, 340, 991-994 (2013).
Selected in Methods to Watch, "Tiny tools to measure force", Nature Methods, 11, 29 (2014).
Selected in Research Highlights, "The Pull of a Cell", Nature Methods, 10, 696-687 (2013).

X. Wang, M. Zhao, and D. D. Nolte, "Molecular layer detection on a diffractive optical balance", Optics Letters, 37, 4098-4100 (2012).

X. Wang, M. Zhao, D. D. Nolte, and T. L. Ratliff, "Prostate specific antigen detection in patient sera by fluorescence-free BioCD protein array", Biosensors & Bioelectronics, 26, 1871-1875 (2011).

X. Wang, M. Zhao, and D. D. Nolte, "Refractive index and dielectric constant transition of ultra-thin gold from cluster to Film", Optics Express, 18, 24859-24867 (2010).

M. Zhao, X. Wang, and D. D. Nolte, "Mass-transport limitations in spot-based microarrays", Biomedical Optics Express, 1, 983-997 (2010).

X. Wang, M. Zhao, and D. D. Nolte, "Ambient Molecular Water Accumulation on Silica Surfaces Detected by a Reflectance Interference Optical Balance", Applied Physics Letters, 97, (2010).

D. D. Nolte, M. Zhao and X. Wang, The BioCD: High-Speed Interferometric Optical Biosensor, Integrated Analytical Systems, Springer-Verlag New York, Book Chapter, (2009)

X. Wang, M. Zhao, and D. D. Nolte, "Optical contrast and clarity of graphene on an arbitrary substrate", Applied Physics Letters, 95, 081102 (2009).

Selected in Virtual Journal of Nanoscale Science & Technology.

X. Wang, M. Zhao, and D. D. Nolte, "Prostate-specific antigen immunoassays on the BioCD," Analytical and Bioanalytical Chemistry, 393, 1151-1156 (2009).

X. Wang, Y. P. Chen, and D. D. Nolte, "Strong anomalous optical dispersion of graphene: complex refractive index measured by Picometrology," Optics Express, 16, 22105-22112 (2008).

X. Wang, M. Zhao, and D. D. Nolte, "Land-contrast self-referencing interferometric protein microarray," Applied Physics Letters, 93, (2008).

Selected in Research Highlights, "Protein Interference", Nature Physics, 5, 9 (2009)

X. Wang, M. Zhao, and D. D. Nolte, "Area-scaling of interferometric and fluorescent detection of protein on antibody microarrays," Biosensors & Bioelectronics, 24, 981-987 (2008).

X. Wang, M. Zhao, and D. D. Nolte, "Combined fluorescent and interferometric detection of protein on a BioCD,"Applied Optics, 47, 2779-2789 (2008).

M. Zhao, X. Wang, and D. D. Nolte, "Molecular interferometric imaging," Optics Express, 16, 7102-7118 (2008).

X. Wang, M. Zhao, and D. D. Nolte, "Common-path interferometric detection of protein monolayer on the BioCD,"Applied Optics, 46, 7836-7849 (2007).

X. Wang, Y. Wang, Y. Jiang, and H. Ma, "Two-photon fluorescence anisotropy imaging," Progress in Biochemistry and Biophysics, 32, 161-167 (2005).

Y. Jiang, Y. Wang, Y. Hao, X. Wang, Q. Y. Qiu, Q. F. Wang and H. Ma, "Effect of berberine on the proliferation of human pulmonary carcinoma cells," Chinese Journal of Pathophysiology 21, 2170-2173 (2005).

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CONFERENCE PROCEEDINGS

1. X. Wang, M. Zhao, and D. D. Nolte, "A novel concept for protein microarray: land-contrast BioCD," Proceedings of SPIE 7170, 717003 (2009)
2. M. Zhao, X. Wang, and D. Nolte, "Probing mass-transport and binding inhomogeneity in macromolecular interactions by molecular interferometric imaging," Proceedings of SPIE 7188, 71880O (2009)
3. X. Wang, and D. D. Nolte, "Picometrology of Ultra-thin Gold Film by Spinning-Disc Interferometry," Conference on Lasers and Electro-Optics & Quantum Electronics and Laser Science Conference, Vols 1-9, 454-455 (2008)
4. M. Zhao, X. Wang, and D. Nolte, "Molecular Interferometric Imaging Biosensor to Study Molecular Interactions," 2008 Conference on Lasers and Electro-Optics & Quantum Electronics and Laser Science Conference, Vols 1-9, 1899-1900 (2008)
5. X. Wang, M. Zhao, and D. D. Nolte, "Multiplexed BioCD for prostate specific antigen detection," Proceedings of SPIE 6848, 68480S (2008)
6. M. Zhao, X. Wang, and D. Nolte, "The in-line-quadrature BioCD," Proceedings of SPIE 6447, 64470B (2007)
7. X. Wang, M. Zhao, and D. D. Nolte, "Four-channel optical detection on protein-patterned BioCD," Proceedings of SPIE 6447, 64470L (2007)

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 PATENTS (as the primary inventor)

•   System with extended range of molecular sensing through integrated multi-modal data acquisition. Issued Patent Number: US 7659968 (Licensed to and commercialized by Perfinity Biosciences, Inc.)

•   Method and apparatus for conjugate quadrature interferometric detection of an immunoassay. Issued Patent Number: US 7787126 (Licensed to and commercialized by Perfinity Biosciences, Inc.)

•   Balanced-quadrature interferometric protein microarray.  WIPO Patent Publication number: WO/2010/039147