Model of Classical Nuclear Import

(Stewart et al., 2001)

1.  The cargo protein is bound by carrier proteins in the cytoplasm.

2.  The carrier-cargo complex is transported through the nuclear pore complex into the nucleus.

3.  In the nucleus, RanGTP binds and causes the complex to dissociate.

4.  The carrier-RanGTP complex is transported through the NPC to the cytoplasm.

5.  RanGAP activates RanGTPase activity and the carrier-RanGTP complex dissociates.  

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More about the involvement of Ran in nuclear import

Reference 5

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