Mediation of Transport by the NPC
Common features of the nucleoporins:
 | Contain FXFG, GLFG, FG sequence motifs |
| Nucleoporins that interact with transport factors: |
| Nup 153, Tpr, Nup159, Nup116, Nup100, Nsp1, Nup53 (Stoffler et al. 1999) |
| FG nucleoporins located on both the nuclear and cytoplasmic areas of the NPC (Stewart et al. 2001) |
| Nup153, 98, CAN/Nup214, Nup116 interact with members of the importin ß family (Stoffler et al. 1999) |
One model for transport across the pore: "binding site tracks"
| Molecules moving through the pore are transported by a series of attaching and detaching to specific nucleoporins |
| Directionality could possibly be established by different binding tracks (Allen et al. 2000) |
| Different substrates appear to be transported using different tracks (Stewart et al. 2001) |
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