Classical Nuclear Localization Signals:

These sequences are bound by importin α

2 types of classical NLS:

monopartite:  3-5 basic amino acids
bipartite:  basic dipeptide upstream of simple basic sequence

Other Nuclear Localization Signals:

Found in hnRNP proteins, ribosomal proteins, and U snRNPs

(Gorlich and Kutay 1999)

 

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