Carolyn M. Price
Dept. Cancer and Cell Biology
Vontz Center for Molecular Studies
3125 Eden Ave.
Cincinnati, OH 45267
(513) 558-0450 office
(513) 558-5422 fax
Research Interests
Telomere biology: Identity and function of vertebrate telomere proteins, mechanisms of telomere replication in ciliates.
Education
1973-1977 B.Sc. Biochemistry, May 1977. University of St. Andrews, St. Andrews, Scotland. Research area: Drug resistance in extremely halophilic bacteria. Dr. Steven Bayne, research advisor.
1980-1985 Ph.D. Biochemistry, March 1985. University of Colorado Health Sciences Center, Denver, Colorado. Research area: NuMA, a nuclear protein that becomes associated with the mitotic apparatus during cell division. Dr. David Pettijohn, thesis advisor.
1985-1988 Postdoctoral Research. University of Colorado, Boulder, Colorado. Research area: Telomere structure in Oxytricha nova. Dr. Thomas Cech, research advisor.
Academic Positions
1988-94 Assistant Professor of Chemistry. University of Nebraska, Lincoln, Nebraska.
1994 Associate Professor of Chemistry. University of Nebraska, Lincoln, Nebraska. Tenured 8/94.
1994-2000 Associate Professor of Biochemistry and Chemistry. University of Nebraska, Lincoln, Nebraska.
1997-98 Visiting Professor, Rockefeller University, New York
2000-2006 Associate Professor of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati Medical Center
2006-present Professor of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati Medical Center
2006-2008 Professor of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati Medical Center
2008-present Professor Cancer and Cell Biology, University of Cincinnati Medical Center
2008-present Graduate Fellow, University of Cincinnati
Awards
1985-88 Damon Runyon-Walter Winchell Cancer Fund Postdoctoral Fellowship
1985 NIH USPHS Postdoctoral Fellowship (declined)
1989-92 March of Dimes Basil O’Connor Starter Scholar Research Award
1991-94 American Cancer Society Junior Faculty Research Award
1997 Chromosoma Prize for the outstanding paper of the year
1997-1998 NIH Senior Fellowship
1998-1999 NSF Career Advancement Award
Professional Honors and Service
Past
1993-96 Editorial board for Chromosome Research.
1995 Session Chair for International Symposium On Protein Structure Function Relationships (Karachi, Pakistan)
1995-98 Editorial board for Journal of Eukaryotic Microbiology
1996 Ad hoc reviewer for NIH Molecular Cytology study section
1996 Organizer Nebraska Dept. Health Symposium on Cancer Smoking Diseases.
1996-97 Nominating committee for the Society of Protozoologists
1996-2000 Permanent member NIH Molecular Cytology (now CDF-2) Study Section
1997 Co-Chair for FASEB Conference on Ciliate Molecular Biology
1999 Co-Chair for NIH workshop on Chromatin and DNA replication
1999 Co-Organizer Eppley Institute Short Course on Cancer Biology
2003-2009 Ad hoc reviewer for NIH Cell Development and Function (CDF1), Radiation Therapeutics and Biology (RTB), Developmental Therapeutics (DT), Molecular Genetics A (MGA) study sections, Nuclear Development and Transport (NDT), Molecular Genetics c (MGC), and ZRG1 BDA-M 02 study sections
2007 Chair of FASEB conference on Ciliate Molecular Biology
Ongoing
Review for: Mol.Cell, Cell, EMBO J., PLOS, Nat. Str. Mol. Biol., Nucl. Acids Res., Biochemistry, J. Biol. Chem., PNAS, Mol. Cell. Biol., Mol. Biol. Cell, Science, J. Mol. Biol.
1994-present Ad hoc reviewer for the National Science Foundation. Provide occasional reviews for the Israeli Science Foundation, Cancer Research UK, the Italian Research Foundation, the Israel Binational Science Foundation, the German Science Foundation, French CNRS ATIP, the Philip Morris Foundation, Welcome Trust, Israeli Cancer Research Fund, Italian Association for Cancer Research, and Human Frontiers of Science
Recent Invited Lectures and Conference Presentations
2005 Alfred I. DuPont Hospital for Children Wilmington Delaware
2005 Cold Spring Harbor Conference on Telomeres
2005 Genome Research Institute, University of Cincinnati
2005 FASEB Conference on Ciliate Molecular Biology
2005 National University of Ireland, Galway, Ireland Dept. Biochemistry
2005 University of Newcastle, England
2005 Cancer Research UK, London, England
2006 European Conference on Telomeres and Genome Stability
2006 Tolmach Symposium on Telomeres and DNA Repair
2006 University of Minnesota, Dept. Biochemistry, Molecular Biology and Biophysics
2007 McMaster University, Dept. Biology
2007 Cech Symposium, Boulder Colorado
2007 Cleveland State University
2007 Stowers Institute, Kansas City
2007 Texas A&M University, Dept. Biochemistry
2008 Nottingham University, Nottingham, England
2008 2008 EMBO Conference on Telomeres and the DNA Damage Response, Villars, Switzerland
2008 International 3R Symposium (Replication, Repair, Recombination) Tsumagoi, Japan
2008 GEOC Symposium on Chromosome Structure, Tokyo, Japan
2008 University of Michigan, Ann Arbor, Michigan
2009 Cancer and Cell Biology, University of Cincinnati, Cincinnati, Ohio
2009 Cold Spring Harbor Conference on Telomeres
2009 Keystone Meeting, Ashland, Australia
Publications
Price, C. M., McCarty, G. A., Pettijohn, D. E. 1984. NuMA protein is a human autoantigen. Arthritis and Rheumatism 27, 775-779.
Pettijohn, D. E., Henzl, M., Price, C. M. 1984. Nuclear proteins which become part of the mitotic apparatus: A role in nuclear assembly? J. Cell Sci., Sup. 1, 187-201.
Price, C. M. and Pettijohn, D. E. 1986. Redistribution of the nuclear mitotic apparatus protein (NuMA) during mitosis and nuclear reassembly. Exp. Cell Res. 166, 295-311.
Pettijohn, D. E. and Price, C. M. 1987. Nuclear proteins of the mitotic apparatus. In Chromosome and Chromatin Structure Vol. III. Editor K. Adolph. CRC Press.
Price, C. M. and Cech T. R. 1987. Telomeric DNA-protein interactions of Oxytricha macronuclear DNA. Genes Dev. 1, 783-793.
Price, C. M. and Cech T. R. 1989. Properties of the telomeric DNA-binding protein of
Oxytricha nova. Biochemistry 28, 769-774.
Hicke, B., Celander, D., MacDonald, G. H., Price, C. M., Cech, T. R. 1990. Two versions of the gene encoding the 41 kDa subunit of the telomere binding protein of Oxytricha nova. Proc. Natl. Acad. Sci. USA. 87, 1481-1485.
Price, C. M. 1990. Telomere structure in Euplotes crassus: Characterization of DNA-protein interactions and isolation of a telomere binding protein. Mol. Cell. Biol. 10, 3421-3431.
Gray, J. T., Celander D. W., Price, C. M., Cech, T. R. 1991. Cloning and expression of genes for the Oxytricha telomere-binding protein: Specific subunit interactions involved in the formation of the telomeric complex. Cell. 67, 807-814.
Thomas, L. L., and Price, C. M. 1992. Cellular uptake and degradation of phosphorothioate oligonucleotides by marine and freshwater ciliates. Antisense Res. Dev. 2, 251-256.
Price, C. M., Skopp, R., Krueger, J., Williams, D. 1992. DNA recognition and binding by the Euplotes telomere protein. Biochemistry. 31, 16835-10843.
Price, C. M. 1992. Centromeres and Telomeres. Cur. Opin. Cell Biology 4, 379-384.
Wang, W-L., Skopp, R., Scofield, M., Price, C. M. 1992. Euplotes has genes encoding telomere-binding proteins and telomere-binding protein homologs. Nucl. Acids Res. 20, 6621-6629.
Vermeesch, J. R., Williams, D., Price C. M. 1993 Telomere processing in Euplotes. Nucl. Acids Res. 23, 5366-5371.
Price, C. M. 1993. Telomere structure and function. Indian Journal of Biochemistry and Biophysics. 30, 77-82.
Shippen, D. E., Blackburn, E. H., Price C. M. 1994. DNA bound by the Oxytricha telomere protein is accessible to telomerase and other DNA polymerases. Proc. Nat. Acad. Sci. USA, 91, 405-409.
Vermeesch, J. R. and Price C. M. 1994. Telomeric DNA sequence and structure following de novo telomere synthesis in Euplotes crassus. Mol. Cell. Biol. 14, 554-566.
Price, C. M., Adams, A. K., Vermeesch, J. R. 1994. Accumulation of telomerase RNA and telomere protein transcripts during telomere synthesis in Euplotes. J. Eukaryotic Microbiol. 4, 267-275.
Price, C. M. 1995. Telomere-binding proteins of ciliated protozoa. Nucleic Acids & Molecular Biology. F. Eckstein and D. Lilley eds. Springer-Verlag. Volume 9, pp. 299-307.
Skopp, R. S., Wang, W., Price, C. M. 1996. rTP: a candidate telomere protein that is associated with DNA replication. Chromosoma. 105, 82-91
Price, C. M. 1996. Telomeres. Science 271, 455-456.
Price, C. M. 1996. Ciliate telomere proteins. Proceedings of the 4th International Symposium on Protein Structure Function Relationship. Z. Saidi and D. Smith Eds. Plenum Press. pp.175-182.
Carlson, D., Skopp, R., Price, C. 1997. DNA-binding properties of the replication Telomere Protein. Biochemistry, 36, 1590-15908.
Fan, X., Price C. M. 1997. Coordinate regulation of telomeric G- and C-strand length during de novo telomere synthesis. Mol. Biol. Cell. 8, 2145-2155.
Price, C. M. 1997. Synthesis of the telomeric C-strand. Biochemistry (Moscow), 62, 1216-1223.
Klobutcher, L. A., Gygax, S. E., Podoloff, J. D., Vermeesch, J. R., Price, C. M., Tebeau, C. M. and Jahn, C. L. 1998. Conserved DNA sequences adjacent to chromosome fragmentation and telomere addition sites in Euplotes crassus. Nucl. Acids. Res. 18, 4230-4240.
Venkatesan, R. N., Price, C. M. 1998. Telomerase expression in chickens: constitutive activity in somatic tissues and down regulation in culture. Proc. Natl. Acad. Sci. USA. 95, 14763-14768.
Price, C. M. 1999. Capping off the end. Nature, 397, 213-214.
Price, C. M. 1999. Telomeres and telomerase: Broad effects on cell growth. Curr. Opin. Genet. Dev. 9, 218-224.
Ray, S., Tebeau, C. M., Larson, M. A., Jahn, C. L., and Price, C. M. 1999. Euplotes crassus has two histone H1 genes that are differentially expressed during development. Gene 231, 15-20.
Yamaguchi-Iwai, Y., Sonoda, E., Sasaki, M. S., Morrison, C., Haraguchi, T., Hiraoka, Y., Yamashita, Y, M., Takata, M., Price, C., Kakazu, N., Takeda, S. 1999. Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells. EMBO J. 18, 6619-6629.
Price, C. M 2001. Telomeric and subtelomeric repeats. Encyclopedia of the Human Genome. In press.
Price, C. M. 2001. How many proteins does it take to maintain a telomere. Trends in Genetics. 17, 437-438.
Jacob, N K., Skopp, R., Price, C M.. 2001. G-overhang dynamics at Tetrahymena telomeres. EMBO J. 20, 4299-4308.
Ray, S., Wang, L., Shippen, D., Price, C. 2002. Interactions between telomerase and primase physically link the telomere and chromosome replication machinery. Mol. Cell. Biol. 22, 5859-5868.
Wei, C., Skopp, R., Takata, M., Takeda, S. Price, C. M. 2002. Effects of double-strand break repair proteins on vertebrate telomere structure. Nucl. Acids Res. 30, 2862-287.
Tan, M., Jahn, C. L., Price, C. M. 2003. Origin usage during Euplotes ribosomal DNA amplification. Euk. Cell. 2, 115-122
De Rycker, M., Venkatesan, R., Wei, C., Price, C. M. 2003. Vertebrate tankyrase domain structure and sterile-alpha motif (SAM) mediated multimerization. Bioch. J. 372, 87-96.
Jacob, N. K., Kirk, K., Price, C. M. 2003. Generation of telomeric G-strand overhangs involves both G- and C-strand cleavage. Mol. Cell 11, 1021-1032
Wei, C. and Price, C. M. 2003. Protecting the terminus: t-loops and telomere end-binding proteins. Cell. Mol. Life Sci. 60, 2283-2294.
Wei, C., Price, C. M. 2004. Cell cycle localization, dimerization and binding domain architecture of the telomere protein cPot1. Mol. Cell. Biol.24, 2091-2102.
Jacob, N. K., Stout, A. R., Price, C. M. 2004. Modulation of telomere length dynamics by the subtelomeric region of Tetrahymena telomeres. Mol. Biol. Cell. 8, 3719-3728.
Price, C.M. and Jacob, N.K. 2005. Engineering the End: DNA processing at human telomeres. Mol. Cell. 18, 147-148.
Price, C.M. 2006. Ciliate Telomeres. In "Telomeres" E. Blackburn, T. de Lange, V. Lundblad eds. Cold Spring Harbor Press.
Churikov, D., Wei, C. and Price, C.M. 2006. Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection. Mol. Cell. Biol. 26, 6971-6982.
Price, C.M. 2006. Stirring the POT1: surprises in Telomere Protection. Nat. Str. Biol. 13, 673-674.
Jacob, N.K., Linger, B., Lescasse, R., Price, C.M. 2007. Tetrahymena POT1a regulates telomere length but is not required for correct G-overhang processing. Mol. Cell. Biol. 27, 1592-601.
Price, C.M. 2007. wRAPing up the end to prevent telomere fusions. Mol. Cell. 26, 463-464.
Churikov, D., Price, C.M. 2007. Telomeric and Subtelomeric Repeat Sequences. Encyclopedia of Life Sciences. Pub. Online. DOI:10.1002/9780470015902.a0005065.pub2
Churikov, D. Price, C.M. 2007. Pot1 and cell cycle progression cooperate in telomere length regulation. Nat. Str. Mol. Biol. 15, 79-84.
Churikov, D. and Price, C.M. 2008. Pot1 and cell cycle progression cooperate in telomere length regulation. Nat. Str. Mol. Biol. 15, 79-84.
Price, C.M. 2009. Antics at the telomere: uncoupled polymerases solve the end replication problem. EMBO J. 28, 795-6.
Surovtseva, Y.V., Churikov, D., Boltz, K.A., Song, X., Lamb, J., Warrington, R., Leehy, K., Heacock, M., Price, C.M., and Shippen, D.E. 2009. Conserved Telomere Capping protein 1 interacts with Stn1 and protects chromosome ends in higher eukaryotes. Under revision for Molecular Cell.
Linger, B. and Price, C.M. 2009. Conservation of telomere protein complexes: Shuffling through evolution. Critical Reviews in Biochemistry and Molecular Biology. Submitted.
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