Published papers: Click here to see Sean's "My NCBI" publication list and here to see Amy's.


"Conformational Flexibility of Apolipoprotein A-I Amino- and Carboxy- Termini is Necessary for Lipid Binding but Not Cholesterol Efflux"        (Journal of Lipid Research, 2022)


"Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue"        (Nature Scientific Reports, 2021)

"Enterically derived high-density lipoprotein restrains liver injury through the portal vein"        (Science, 2021)

"Apolipoprotein A-I modulates HDL particle size in the absence of apolipoprotein A-II"        (Journal of Lipid Research, 2021)

"Pregnancy is accompanied by larger high-density lipoprotein particles and compositionally distinct subspecies"        (Journal of Lipid Research, 2021)

"The Difference Between High Density Lipoprotein Subfractions and Subspecies: An Evolving Model in Cardiovascular Disease and Diabetes "        (Current Atherosclerosis Reports, 2021)

"The HDL Proteome Watch: Compilation of Studies Leads to New Insights on HDL Function"        (Biochimica Biophysica Acta Molecular and Cellular Biology of Lipids, 2021)

"Apolipoprotein E Content of VLDL Limits LPL-mediated Triglyceride Hydrolysis"        (Journal of Lipid Research, 2021)


"Functional Recombinant Apolipoprotein A5 that is Stable at High Concentrations at Physiological pH"        (Journal of Lipid Research, 2020)

"Characterization of LP-Z Lipoprotein Particles and Quantification in Subjects with Liver Disease Using a Newly Developed NMR-Based Assay"        (Journal of Clinical Medicine, 2020)

"Protein-Defined Subspecies of HDLs (High-Density Lipoproteins) and Differential Risk of Coronary Heart Disease in 4 Prospective Studies. "        (Atherosclerosis, Thrombosis and Vascular Biology, 2020)


"Albuminuria, the HDL (High-Density Lipoprotein) Proteome, and Coronary Artery Calcification in Type 1 Diabetes Mellitus "        (Atherosclerosis, Thrombosis and Vascular Biology, 2019)

"Modified sites and functional consequences of 4-oxo-2-nonenal adducts in HDL that are elevated in familial hypercholesterolemia "        (Journal of Biological Chemistry, 2019)


"Distinct Proteomic Signatures in 16 HDL Subspecies"        (Atherosclerosis, Thrombosis and Vascular Biology, 2018)

"Feasibility of a Plasma Bioassay to Assess Oxidative Protection of Low Density Lipoproteins by High Density Lipoproteins"  (Editorial Comment)        (Journal of Clinical Lipidology, 2018)

"Apolipoprotien A-IV is a Novel Ligand of Platelet ?IIb?3 Integrin and Inhibits Thrombosis"        (Nature Communications, 2018)

"A Thumbwheel Mechanism for APOA1 Activation of LCAT Activity in HDL"  (Online supplement);       (Journal of Lipid Research, 2018)

"Apolipoprotein A-IV Enhances Cholecystokinin Secretion"        (Physiology and Behavior, 2018)

"High-Density Lipoproteins-Associated Proteins and Subspecies Related to Arterial Stiffness in Young Adults with Type 2 Diabetes Mellitus"        (Complexity, 2018)

"Loss of MicroRNA-128 Promotes Cardiomyocyte Proliferation and Heart Regeneration"        (Nature Communications, 2018)

"Characterizing Homodimer Interfaces with Cross-linking Mass Spectrometry and Isotopically-labelled Proteins"        (Nature Protocols, 2018)


"Silencing Steroid Receptor Coactivator-1 in the Nucleus of the Solitary Tract Reduces Estrogenic Effects of Feeding and Apolipoprotein A-IV Expression"       (Journal of Biological Chemistry, 2017)

"Studies in genetically modified mice implicate maternal HDL as a mediator of fetal growth"       (FASEB Journal, 2017)

"A Consensus Model of Human Apolipoprotein A-I in its Monomeric and Lipid-free State"  (Online supplement);       (Nature Structure and Molecular Biology, 2017)

"Obesity is Associated with an Altered HDL Subspecies Profile Among Adolescents with Metabolic Disease"  (Online supplement);      (Journal of Lipid Research, 2017)

"Apolipoprotein A-II Alters the Proteome of Human Apolipoproteins and Enhances Cholesterol Efflux from ABCA1"  (Online supplement);       (Journal of Lipid Research, 2017)

"High Density Lipoproteins Selectively Promote the Survival of Human Regulatory T-cells"  (Online supplement);       (Journal of Lipid Research, 2017)


"Weight Loss Surgery in Adolescents Corrects High Density Lipoprotein Subspecies and their Function"       (International Journal of Pediatric Obesity, 2016)

"Impact of Genetic Deletion of Platform Apolipoproteins on the Size Distribution of the Murine Lipoproteome"       (Journal of Proteomics, 2016)

"Clinical Feature: The Continuing Saga or HDL: Truth, Fallacy, or Something in Between?"       (Lipid Spin, a publication of the National Lipid Association, 2016)

"Speciated High-Density Lipoprotein Biogenesis and Functionality"       (Current Atherosclerosis Reports, 2016)

"The Effects of Apolipoprotein B Depletion on HDL Subspecies Composition and Function"        (Journal of Lipid Research, 2016)

"An Evaluation of the Crystal Structure of C-terminal Truncated Apolipoprotein A-I in Solution Reveals Structural Dynamics Related to Lipid Binding"        (Journal of Biological Chemistry, 2016)


"Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes"       (Journal of Proteome Research, 2015)

"A Comparison of Methods to Enhance Protein Detection of Lipoproteins by Mass Spectrometry"       (Journal of Proteome Research, 2015)

"A Comparison of the Mouse and Human Lipoproteome: Suitability of the Mouse Model for Studies of Human Lipoproteins"       (Journal of Proteome Research, 2015)

"Structure of HDL: Particle Subclasses and Molecular Components"        (Handbook of Experimental Pharmacology, 2015)

"Role of Conserved Proline Residues in Human Apolipoprotein A-IV Structure and Function"        (Journal of Biological Chemistry, 2015)


"HDL-C vs HDL-P: How changing one letter could make a difference in understanding the role of high-density lipoprotein in disease"        (Clinical Chemistry, 2014)

"The structure of human apolipoprotein A-IV as revealed by stable isotope-assisted cross-linking, molecular dynamics, and small angle X-ray scattering"        (Journal of Biological Chemistry, 2014)

"A tribute to the Philadelphia Lipid Group on the occasion of ther retirement"       (Journal of Lipid Research, 2014)


"Multi-dimensional co-separation analysis reveals protein-protein interactions defining plasma lipoprotein subspecies"  (Online supplement);       (Molecular and Cellular Proteomics, 2013)

"The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male youth" (Online supplement); (Invited commentary article appearing in same issue);       (Diabetes, 2013)

"Helical domains that mediate lipid solubilization and ABCA1-specific cholesterol efflux in apolipoproteins C-I and A-II"  (Online supplement);       (Journal of Lipid Research, 2013)

"Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond"        (Journal of Lipid Research, 2013)

"Small-angle X-ray scattering of apolipoprotein A-IV reveals the importance of its termini for structural stability"        (Journal of Biological Chemistry, 2013)

"High yield expression and purification of human apolipoprotein A-II in Escherichia Coli"        (Journal of Lipid Research, 2013)


"The structure of apolipoprotein A-IV and its mechanism of self-association "  (Online supplement); (PDB file 3S84); (Cover image);       (Structure, 2012)

"Apolipoprotein A-I mimetics and high density lipoprotein function "     (Current Opinion in Endocrinology Diabetes and Obesity, 2012)


"Apolipoprotein A-I structural organization in high density lipoprotein particles isolated from human plasma "  (Online supplement);   (Nature Structural and Molecular Biology, 2011)

"HDL: Its not just about lipid transport anymore "  (Cover image);   (Trends in Endocrinology and Metabolism, 2011)


"Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration chromatography ":    (Journal of Proteome Research, 2010)

"High-density lipoprotein proteomics: Identifying new drug targets and biomarkers by understanding functionality (Review) ":    (Current Cardiovascular Risk Reports, 2010)


"The role of hydrophobic and negatively charged surface patches of lipid-free apolipoprotein A-I on lipid binding and ABCA1-mediated cholesterol efflux":    (Biochemica Biophysica Acta, 2009)

"Purification of recombinant apolipoproteins AI and A-IV and efficient affinity tag cleavage by tobacco etch virus protease":    (Journal of Lipid Research, 2009)

"Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function":    (Arteriosclerosis, Thrombosis and Vascular Biology, 2009)


"Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes"  (Online supplement)  (PNAS In This Issue):    (The Proceedings of the National Academy of Sciences, 2008)

"A three-dimensional homology model of lipid-free apolipoprotein A-IV using cross-linking and mass spectrometry":    (The Journal of Biological Chemistry, 2008)

"An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages"  (Online supplement)   (Cover image)    (The Journal of Lipid Research, 2008)

"Annals of Medicine Review: Apolipoprotein A-I structure in high-density lipoproteins":    (The Annals of Medicine, 2008)


"JBC MINIREVIEW: The structure of apolipoprotein A-I in high density lipoproteins":    (The Journal of Biological Chemistry, 2007)

"Modulation of apolipoprotein A-IV lipid binding by an interaction between the N and C termini":    (The Journal of Biological Chemistry, 2007)

"The structure of apolipoprotein A-II in discoidal high density lipoproteins":    (The Journal of Biological Chemistry, 2007)


"Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I":    (The Journal of Lipid Research, 2006)

"The biotin-capture lipid affinity assay: a rapid method for determining lipid binding parameters for apolipoproteins":    (The Journal of Lipid Research, 2006)

"Apolipoprotein A-IV interacts synergystically with melanocortins to reduce food intake":    (American Journal of Physiology, 2006)


"Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association":    (The Journal of Biological Chemistry, 2005)

"Current Opinion in Lipidology Review: Apolipoprotein structural organization in high density lipoproteins: belts, bundles, hinges and hairpins":    (Current Opinion in Lipidology, 2005)

"A mass spectrometric determination of the conformation of dimeric apolipoprotein A-I in discoidal high density lipoproteins":    (Biochemistry, 2005)

"Bacterial expression and characterization of rat apolipoprotein E":    (Protein Expression and Purification, 2005)

"A three-dimensional molecular model of lipid-free apolipoprotein A-I determined by cross-linking/mass spectrometry and sequence threading":    (Biochemistry, 2005)


"Identification and structural ramifications of a hinge domain in apolipoprotein A-I discoidal high-density lipoproteins of different size":    (Biochemistry, 2004)

"Structure of human apolipoprotein A-IV: A distinct domain architecture among exchangeable apolipoproteins with potential functional implications":    (Biochemistry, 2004)

"Helix orientation of the functional domains in apolipoprotein E in discoidal high density lipoprotein particles":    (The Journal of Biological Chemistry, 2004)


"Ceramide increases cholesterol efflux to apoliprotein A-I by increasing the cell surface expression of ABCA1":    (The Journal of Biological Chemistry, 2003)

"The spatial organization of apolipoprotein A-I on the edge of reconsituted high density lipoprotein particles: A mass spectrometry study":    (The Journal of Biological Chemistry, 2003)


"The role of apolipoprotein A-I in helix 10 of apolipoprotein-mediated cholesterol efflux via the ATP-binding cassette transporter ABCA1":    (The Journal of Biological Chemistry, 2002)

"Bacterial expression and characterization of mature apolipoprotein A-I":    (Protein Expression and Purification, 2002)


"Apolipoprotein A-I adopts a belt-like orientation in reconstituted high density lipoproteins":    (The Journal of Biological Chemistry, 2001)

"A proteolytic method for distinguishing between lipid-free and lipid-bound apolipoprotein A-I":   (Journal of Lipid Research, 2001)


"The orientation of helix 4 of apolipoprotein A-I in reconstituted discoidal high density lipoproteins":    (The Journal of Biological Chemistry, 2000)


Sean's NIH Biosketch