Nuclear Fusion reactions combine light nuclei into heavier nuclei to release energy. Since protons have like charges, they don't want to combine! However, in the center of the Sun, densities are extremely high and the particles hit each other with such high speeds (due to their hot temperature), as to overcome this Coulomb Barrier.
Iron has the most tightly bound nucleus. You can not generate ANY energy once you arrive at Iron, via fusion or fission.