With the exception of the Supernova, and a few other techniques still being developed, the most distant sources in our galaxy are measured based on the expansion of the universe. Hubble was the first to notice that the more distant a galaxy was, the higher its speed away from us was.. (Doppler Shifted Spectrum)
Plotting distance verses its speed, Hubble came up with the Hubble Law.
Ho
is the Hubble Constant, measured in
velocity per distance (km/s per Mega parsec).