HDL Proteome Watch:
Current official count: 95 proteins*
*defined as appearing in 3 separate reports from 3 independent laboratories
It is becoming clear that HDL is not just one entity. Unbiased proteomic studies are showing that HDL contains numerous proteins and lipids that may segregate into distinct subclasses. As a result of differences in instruments, sensitivity, HDL isolation technique, patient donors etc., the total "list" of HDL proteins can vary dramatically from study to study. To try to make sense of this, we have consolidated all existing data so that a more realistic estimate of the HDL proteome can be determined. We compared some 17 different proteomics studies that, 1) used modern high-resolution proteomics techniques, 2) studied HUMAN HDL samples isolated by a variety of techniques, and 3) made thier raw data publically available. We also included other proteins that have been found to be associated with HDL through other biochemical techniques such as immunoprecipitation and in vitro binding studies.
The spreadsheet is in Excel format and is freely available to the scientific community. The identified proteins have been hyperlinked to the Uniprot Protein Knowledgebase so that the details and functions of each protein can be easily accessed.
We encourage you to use the list and cite it if you like. If you feel we have left something out, please contact Sean Davidson. We will update the list as quickly and frequently as possible.
Download list here