Since the 1950's, the suicide rate for adolescents has more than tripled and is presently the third leading cause of death among 15 to 24 years olds.  Comprehensive school suicide prevention programs are needed which include primary, secondary and tertiary prevention components.  This paper discusses these components as they relate to suicide prevention and provides practical steps to incorporating each within a school system.  All steps are based on a review of the professional literature.  The following questions are explored:  What can school professionals do to help in preventing adolescent suicide?  What should school professionals do when a student threatens suicide?  What should school professionals do after a student commits suicide?  It is a hope that this review will assist school professionals in developing their own comprehensive school suicide prevention programs.  This article is currently in press and set for an April publication in the Journal of School Health.